Current Issue : January-March Volume : 2012 Issue Number : 1 Articles : 3 Articles
Aceclofenac, a non steroidal anti-inflammatory agent is BCS class II drug (highly permeable and low soluble) shows poor aqueous solubility in order to improve solubility and dissolution rate; nanoparticles of Aceclofenac were prepared. Nanoparticle engineering offers promising methods for the formulation of poorly water soluble drug compounds. The aim of the present work was to enhance dissolution of poorly water-soluble Aceclofenac by preparing stable nanoparticles. Mechanism of dissolution enhancement was also investigated. nanoparticles were produced by combining the antisolvent precipitation and High Pressure Homogenization (HPH) approaches in the presence of HPMC E5 and SDS (2.5:1.5, w/w). Then the nanosuspensions were converted into dry powders by spray-drying. The effect of process variables on particle size and physical state of drug were investigated. The physicochemical properties of pure drug and nanoparticles were characterized by Scanning Electron Microscopy (SEM). The images of SEM revealed spherical nanoparticles. Nanoparticles showed good dissolution profile. The process by combining the antisolvent precipitation under sonication and HPH was produce small, uniform and stable nanoparticles which markedly enhanced dissolution rate...
The recent developments of floating drug delivery system (FDDS) including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. It is known that differences in gastric physiology, such as, gastric pH, and motility exhibit both intra-as well as inter-subject variability demonstrating significant impact on gastric retention time and drug delivery behavior. This triggered the attention towards formulation of stomach specific (gastro retentive) dosage forms. This dosage forms will be very much useful to deliver ‘narrow absorption window’ drugs. Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices. The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. This review also summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form....
The aim of this article is to review the development of ODTs, challenges in formulation, new ODT technologies and evaluation methodologies, suitability of drug candidates, and future prospects. The purpose of formulation and development of orally disintegrating tablet (ODTs) is who have the problem of swallowing conventional tablets and capsules. ODTs have the unique property of rapidly disintegrating and/or dissolving and releasing the drug as soon as they come in contact with saliva, thus obviating the requirement of water during administration. Over the decades, orally disintegrating tablet (ODTs) has expanded much attention as a preferred alternative to conventional oral dosage form such as tablet and capsules. Recently, ODTs have acquired an important position in the market by who have difficulty in overcoming previously encountered administration problems and contributing to extension of patient life, which includes dysphagic, bed ridden, psychic, geriatric and pediatric patients, Conventional preparation technologies like direct compression, lyophilization, spray drying, molding, phase transition process, melt granulation, sublimation, mass extrusion, etc., while various patented technologies like Zydis, Orasolv, Durasolv, Flash tab, Oraquick, Wow tab, etc., have been developed for the production of ODTs, with evaluate the potential of microspheres for taste masking when incorporated into orally disintegrating tablets including the use of superdisintegants. The present review addresses briefly about the current developments in ODT technologies and various leading technologies for their manufacturing. In addition, important aspects of ODT technology are discussed....
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